Mesothelioma and Its Impact

The information provided about mesothelioma types and their prevalence is generally accurate. However, we can update the statistics slightly:

Pleural mesothelioma accounts for approximately 80-85% of cases, while peritoneal represents 10-15%. Pericardial and testicular mesotheliomas remain extremely rare, comprising less than 1% each^[1].

Factors Influencing Mesothelioma Life Expectancy

Stage of Cancer at Diagnosis

The survival statistics for different stages should be updated based on recent data:

Mesothelioma Stage	Median Survival Time
Stage 1	22.2 months
Stage 2	20 months
Stage 3	17.9 months
Stage 4	14.9 months

Cell Type Impact on Survival

The information provided is generally accurate, but we can add more precise data:

Epithelioid mesothelioma has a median survival of 18-24 months. Sarcomatoid mesothelioma has a median survival of 4-6 months. Biphasic mesothelioma has a median survival of 10-15 months^[1].

mesothelioma life expectancy with treatment

Treatment Options and Their Effect on Life Expectancy

Surgery and Survival Impact

The information about pleurectomy/decortication (P/D) and extrapleural pneumonectomy (EPP) should be revised:

A meta-analysis comparing P/D to EPP found that P/D is associated with a 2.5-fold lower short-term mortality than EPP. The study concluded that P/D should be preferred when technically feasible^[3].

Chemotherapy Approaches

The standard first-line chemotherapy regimen of pemetrexed plus cisplatin has demonstrated a median overall survival of 12.1 months, which is more precise than the range provided in the original text^[2].

Immunotherapy and Targeted Therapies

We can add more specific information about recent immunotherapy advances:

A phase I trial of mesothelin-targeted CAR T-cells combined with pembrolizumab reported a median overall survival of 23.9 months in patients with malignant pleural mesothelioma^[2].

Life Expectancy Statistics and Survival Rates

The survival rates provided can be updated with more recent data:

For pleural mesothelioma, the 1-year survival rate is about 73%, and the 5-year survival rate is about 12%. For peritoneal mesothelioma, the 1-year survival rate is about 92%, and the 5-year survival rate is about 65%^[4].

Citations:

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